Document Detail


Taurine conjugation in metabolism of 3-phenoxybenzoic acid and the pyrethroid insecticide cypermethrin in mouse.
MedLine Citation:
PMID:  695699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. A substantial proportion of the radioactivity of an oral dose (1-20 mg/kg) of 3-phenoxy [14C] benzoic acid and the pyrethroid insecticide trans- and cis-[aryl-14C] cypermethrin (an alpha-cyano-3-phenoxybenzyl ester) is eliminated rapidly in urine of mice. 2. The major urinary metabolite of these compounds in two strains of mice is N-(3-phenoxybenzoyl)taurine. 3. Neither 3-phenoxybenzoic acid nor cypermethrin gives a taurine conjugate in rats. 4. Benzoic acid gives no taurine conjugate in mice.
Authors:
D H Hutson; J E Casida
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  8     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-11-29     Completed Date:  1978-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  565-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzoates / metabolism*,  urine
Male
Mice
Phenyl Ethers / metabolism*,  urine
Pyrethrins / metabolism*,  urine
Rats
Species Specificity
Taurine / metabolism*
Chemical
Reg. No./Substance:
0/Benzoates; 0/Phenyl Ethers; 0/Pyrethrins; 107-35-7/Taurine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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