| Taurine Ameliorates Impaired the Mitochondrial Function and Prevents Stroke-like Episodes in Patients with MELAS. | |
| | |
MedLine Citation:
|
PMID: 23257519 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective Post-transcriptional taurine modification at the first anticodon ("wobble") nucleotide is deficient in A3243G-mutant mitochondrial (mt) tRNA(Leu(UUR)) of patients with myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Wobble nucleotide modifications in tRNAs have recently been identified to be important in the accurate and efficient deciphering of codons. We herein examined whether taurine can alleviate mitochondrial dysfunction in patient-derived pathogenic cells and prevent clinical symptoms in MELAS patients. Methods and Results The addition of taurine to the culture media ameliorated the reduced oxygen consumption, decreased the mitochondrial membrane potential, and increased the oxidative stress in MELAS patient-derived cells. Moreover, high dose oral administration of taurine (0.25 g/kg/day) completely prevented stroke-like episodes in two MELAS patients for more than nine years. Conclusion Taurine supplementation may be a novel potential treatment option for preventing the stroke-like episodes associated with MELAS. |
| | |
Authors:
|
Mitsue Rikimaru; Yutaka Ohsawa; Alexander M Wolf; Kiyomi Nishimaki; Harumi Ichimiya; Naomi Kamimura; Shin-Ichiro Nishimatsu; Shigeo Ohta; Yoshihide Sunada |
Related Documents
:
|
12640079 - American trypanosomiasis (chagas' disease): an unrecognised cause of stroke. 10456799 - Ideomotor apraxia in alzheimer disease and left hemisphere stroke: limb transitive and ... 3848299 - Cerebral occlusion. extracranial-intracranial anastomosis. 9873159 - Aggravation of acute ischemic stroke by hyperthermia is related to an excitotoxic mecha... 20130399 - Wake-up stroke: clinical and neuroimaging characteristics. 12796539 - The clinical features of 16 cases of stroke associated with administration of ivig. 12640079 - American trypanosomiasis (chagas' disease): an unrecognised cause of stroke. 17288889 - Optic neuritis: the role of disease-modifying therapy in this clinically isolated syndr... 19926019 - Anemia in adults with congenital heart disease relates to adverse outcome. |
Publication Detail:
|
Type: Journal Article Date: 2012-12-15 |
Journal Detail:
|
Title: Internal medicine (Tokyo, Japan) Volume: 51 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
|
Languages: eng Pagination: 3351-7 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Kawasaki Medical School, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pulmonary Computed Tomography Findings in 39 Cases of Streptococcus pneumoniae Pneumonia.
Next Document: Changes in Biomarkers Focused on Differences in Disease Course or Treatment in Patients with Neuro-B...