Document Detail

Taurine activates delayed rectifier Kv channels via a metabotropic pathway in retinal neurons.
MedLine Citation:
PMID:  23045337     Owner:  NLM     Status:  MEDLINE    
Taurine is one of the most abundant amino acids in the retina, throughout the CNS, and in heart and muscle cells. In keeping with its broad tissue distribution, taurine serves as a modulator of numerous basic processes, such as enzyme activity, cell development, myocardial function and cytoprotection. Despite this multitude of functional roles, the precise mechanism underlying taurine's actions has not yet been identified. In this study we report findings that indicate a novel role for taurine in the regulation of voltage-gated delayed rectifier potassium (K(V)) channels in retinal neurons by means of a metabotropic receptor pathway. The metabotropic taurine response was insensitive to the Cl(-) channel blockers, picrotoxin and strychnine, but it was inhibited by a specific serotonin 5-HT(2A) receptor antagonist, MDL11939. Moreover, we found that taurine enhanced K(V) channels via intracellular protein kinase C-mediated pathways. When 5-HT(2A) receptors were expressed in human embryonic kidney cells, taurine and AL34662, a non-specific 5-HT(2) receptor activator, produced a similar regulation of K(IR) channels. In sum, this study provides new evidence that taurine activates a serotonin system, apparently via 5-HT(2A) receptors and related intracellular pathways.
Simon Bulley; Yufei Liu; Harris Ripps; Wen Shen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-08
Journal Detail:
Title:  The Journal of physiology     Volume:  591     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-13     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-32     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Cyclic AMP-Dependent Protein Kinases / physiology
Delayed Rectifier Potassium Channels / physiology*
HEK293 Cells
Protein Kinase C / physiology
Receptor, Serotonin, 5-HT2A / physiology*
Retinal Neurons / drug effects*,  physiology
Taurine / pharmacology*
Grant Support
Reg. No./Substance:
0/Delayed Rectifier Potassium Channels; 0/Receptor, Serotonin, 5-HT2A; 1EQV5MLY3D/Taurine; EC AMP-Dependent Protein Kinases; EC Kinase C

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