Document Detail

Tau, ubiquitin, and alpha B-crystallin immunohistochemistry define the principal causes of degenerative frontotemporal dementia.
MedLine Citation:
PMID:  7575218     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the use of immunostaining with antibodies to tau, ubiquitin, and alpha B-crystallin in defining a protocol for the staged neuropathologic examination of brains from patients with a progressive frontotemporal dementia. DESIGN: Brains obtained from 50 patients dying with the clinical diagnosis of frontotemporal dementia were examined histopathologically to define pathologic distinctions. SETTING: Two university hospital neuropathology departments. RESULTS: Anti-tau immunostaining defined corticobasal degeneration, Alzheimer's disease, and Pick's disease; antiubiquitin defined motor neuron disease with dementia. The remaining brains have frontal lobe degeneration: the use of alpha B-crystallin immunostaining, on these, to detect ballooned neurons may help to define two groups of patients, one of which we believe may represent a variant of Pick's disease. CONCLUSION: These findings indicate that immunostaining with these antibodies is essential for the evaluation of frontal dementia.
P N Cooper; M Jackson; G Lennox; J Lowe; D M Mann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  52     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-11-08     Completed Date:  1995-11-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1011-5     Citation Subset:  AIM; IM    
Department of Pathology, Manchester University Medical School, England.
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MeSH Terms
Antibodies / analysis
Crystallins / analysis*
Dementia / etiology,  metabolism*,  pathology*
Frontal Lobe / metabolism*,  pathology
Temporal Lobe / metabolism*,  pathology
Ubiquitins / analysis*
tau Proteins / analysis*
Reg. No./Substance:
0/Antibodies; 0/Crystallins; 0/Ubiquitins; 0/tau Proteins
Comment In:
Arch Neurol. 1996 Sep;53(9):836   [PMID:  8815844 ]

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