Document Detail


Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer disease.
MedLine Citation:
PMID:  9876968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of tau protein in cerebrospinal fluid (CSF) was determined in 40 patients with clinically diagnosed probable Alzheimer disease (AD) and in 36 cognitively healthy controls. A significant increase of CSF tau was found in the AD patients, even in 19 subjects with very mild dementia as defined by a Mini-Mental State Examination score of 25 and above. Using a cutoff value of 260 pg/mL the sensitivity of elevated tau was 0.89, the specificity was 0.97, and the proportion of correctly allocated cases was 95%. In the AD groups there were no significant associations between CSF tau level and age, age at onset, duration of illness, apolipoprotein E genotype, severity of cognitive impairment, or deficit in regional cerebral blood flow as measured using 99Tm-ethyl cystein dimer single photon emission computed tomography. The findings demonstrate that CSF tau is significantly increased at the earliest clinical stage of AD and shows only minimal overlap with age-matched cognitively healthy controls. This finding suggests that CSF tau could be a biological marker of AD even before dementia has developed.
Authors:
A Kurz; M Riemenschneider; K Buch; F Willoch; P Bartenstein; U Müller; W Guder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  12     ISSN:  0893-0341     ISO Abbreviation:  Alzheimer Dis Assoc Disord     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-18     Completed Date:  1999-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  372-7     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Technische Universität, München, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alzheimer Disease / cerebrospinal fluid,  diagnosis*
Biological Markers / cerebrospinal fluid
Dementia / cerebrospinal fluid,  diagnosis
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Reference Values
Sensitivity and Specificity
tau Proteins / cerebrospinal fluid*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/tau Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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