Document Detail


Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies.
MedLine Citation:
PMID:  11045667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate glial lesions in cases of dementia with Lewy bodies (DLB), we studied the brains of four patients with DLB. Astrocytic star-like inclusions, which resembled tufted astrocytic fibrillary tangles in shape, were found in the cortex of two of these cases. In addition, coiled bodies were found in the white matter of the cerebrum in two cases. The astrocytic star-like inclusions were immunohistochemically negative for tau protein, ubiquitin and alpha-synuclein. The coiled bodies were immunohistochemically negative for tau protein but immunopositive for ubiquitin and alpha-synuclein. These results suggest that in DLB a primary degenerative process takes place in both glial cells and neurons.
Authors:
S Terada; H Ishizu; T Haraguchi; Y Takehisa; Y Tanabe; K Kawai; S Kuroda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  100     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-22     Completed Date:  2001-02-01     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  464-8     Citation Subset:  IM    
Affiliation:
Department of Neuropsychiatry, Okayama University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / pathology
Astrocytes / metabolism*,  ultrastructure*
Brain / pathology
Dementia / pathology*
Female
Humans
Inclusion Bodies / ultrastructure*
Lewy Body Disease / metabolism*,  pathology*
Male
Middle Aged
tau Proteins / metabolism*
Chemical
Reg. No./Substance:
0/tau Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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