Document Detail


Tatumine, a peptide from Bacillus brevis Vm4-572-403.
MedLine Citation:
PMID:  7410204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mutant 572-403 of Bacillus brevis Vm4 was isolated from N-methyl-N'-nitro-N-nitroso guanidine (nitrosoguanidine)-treated cultures of the parental strain. The mutant produces tatumine and edeine B when grown in a defined medium at 40 degrees C. Tatumine is composed of spermidine, glycine, isoserine, and an unidentified ninhydrin-positive compound; it has a molecular weight of less than 730 d (edeine A). It is soluble in water and isopropanol. Tatumine has no antimicrobial activity but has selective cytotoxicity against cultured cells of sarcoma origin. This activity is not destroyed by heating for 1 hour at 60 degrees C.
Authors:
J Heaney-Kieras; Z Kurylo-Borowska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  33     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-11-25     Completed Date:  1980-11-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents*
Antibiotics, Antineoplastic / isolation & purification*
Bacillus / analysis*
Cells, Cultured
Chemical Phenomena
Chemistry
Chemistry, Physical
Humans
Mutation
Peptides / isolation & purification
Physicochemical Phenomena
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antibiotics, Antineoplastic; 0/Peptides; 74188-26-4/tatumine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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