| Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients. | |
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MedLine Citation:
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PMID: 2184372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kaposi's sarcoma (KS) is frequently associated with human immunodeficiency virus-1 (HIV-1) infection. Supernatants from HIV-1-infected T cells carrying the CD4 antigen promote the growth of cells derived from KS lesions of AIDS patients (AIDS-KS cells), and the HIV-1 tat gene, introduced into the germ line of mice, induces skin lesions closely resembling KS. Here we report that the tat gene product (Tat) is released from both HIV-1-acutely infected H9 cells and tat-transfected COS-1 cells. These Tat-containing supernatants specifically promote growth of AIDS-KS cells which are inhibited by anti-Tat antibodies; recombinant Tat has the same growth-promoting properties. Therefore a viral regulatory gene product can be released as a biologically active protein and directly act as a growth stimulator. These and previous data indicate that extracellular Tat could be involved in the development or progression, or both, of KS in HIV-1-infected individuals. |
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Authors:
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B Ensoli; G Barillari; S Z Salahuddin; R C Gallo; F Wong-Staal |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature Volume: 345 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-05-31 Completed Date: 1990-05-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 84-6 Citation Subset: IM; X |
Affiliation:
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Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Cell Division Cell Line Escherichia coli / genetics Gene Expression Gene Products, tat / genetics, physiology* HIV-1 / metabolism* Humans Immunosorbent Techniques Recombinant Proteins / pharmacology Sarcoma, Kaposi / etiology, pathology* Trans-Activators / physiology* Transfection tat Gene Products, Human Immunodeficiency Virus |
| Chemical | |
Reg. No./Substance:
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0/Gene Products, tat; 0/Recombinant Proteins; 0/Trans-Activators; 0/tat Gene Products, Human Immunodeficiency Virus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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