Document Detail


Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients.
MedLine Citation:
PMID:  2184372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kaposi's sarcoma (KS) is frequently associated with human immunodeficiency virus-1 (HIV-1) infection. Supernatants from HIV-1-infected T cells carrying the CD4 antigen promote the growth of cells derived from KS lesions of AIDS patients (AIDS-KS cells), and the HIV-1 tat gene, introduced into the germ line of mice, induces skin lesions closely resembling KS. Here we report that the tat gene product (Tat) is released from both HIV-1-acutely infected H9 cells and tat-transfected COS-1 cells. These Tat-containing supernatants specifically promote growth of AIDS-KS cells which are inhibited by anti-Tat antibodies; recombinant Tat has the same growth-promoting properties. Therefore a viral regulatory gene product can be released as a biologically active protein and directly act as a growth stimulator. These and previous data indicate that extracellular Tat could be involved in the development or progression, or both, of KS in HIV-1-infected individuals.
Authors:
B Ensoli; G Barillari; S Z Salahuddin; R C Gallo; F Wong-Staal
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  345     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-31     Completed Date:  1990-05-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  84-6     Citation Subset:  IM; X    
Affiliation:
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications*
Cell Division
Cell Line
Escherichia coli / genetics
Gene Expression
Gene Products, tat / genetics,  physiology*
HIV-1 / metabolism*
Humans
Immunosorbent Techniques
Recombinant Proteins / pharmacology
Sarcoma, Kaposi / etiology,  pathology*
Trans-Activators / physiology*
Transfection
tat Gene Products, Human Immunodeficiency Virus
Chemical
Reg. No./Substance:
0/Gene Products, tat; 0/Recombinant Proteins; 0/Trans-Activators; 0/tat Gene Products, Human Immunodeficiency Virus

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