Document Detail


Taste receptor signaling in the mammalian gut.
MedLine Citation:
PMID:  18024184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Molecular sensing by gastrointestinal (GI) cells plays a crucial role in the control of multiple fundamental functions including digestion, regulation of caloric intake, pancreatic insulin secretion, and metabolism, as well as protection from ingested harmful drugs and toxins. These processes are likely to be mediated by the initiation of humoral and/or neural pathways through the activation of endocrine cells. However, the initial recognition events and mechanism(s) involved are still largely unknown. This article reviews the current evidence that the chemosensory machinery discovered in specialized neuroepithelial taste receptor cells of the lingual epithelium is operational in enteroendocrine open GI cells that sense the chemical composition of the luminal contents of the gut.
Authors:
Enrique Rozengurt; Catia Sternini
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-11-19
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  7     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-24     Revised Date:  2011-09-26    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-62     Citation Subset:  IM    
Affiliation:
Division of Digestive Diseases and CURE, Digestive Diseases Research Center, David Geffen School of Medicine, University of California at Los Angeles, 900 Veteran Avenue, Los Angeles, CA 90095, USA. erozengurt@mednet.ucla.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Enteroendocrine Cells / metabolism
Gastrointestinal Hormones / physiology
Gastrointestinal Tract / metabolism,  physiology*
Humans
Receptors, G-Protein-Coupled / biosynthesis,  genetics
Signal Transduction / drug effects,  genetics,  physiology*
Taste Buds / drug effects,  physiology*
Transducin / biosynthesis,  genetics
Grant Support
ID/Acronym/Agency:
DK 41301/DK/NIDDK NIH HHS; DK 54155/DK/NIDDK NIH HHS; DK 55003/DK/NIDDK NIH HHS; DK 56930/DK/NIDDK NIH HHS; P30 DK041301-20/DK/NIDDK NIH HHS; R01 DK054155-09A1/DK/NIDDK NIH HHS; R01 DK055003-10A1/DK/NIDDK NIH HHS; R01 DK056930-08/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Receptors, G-Protein-Coupled; 147979-21-3/Gnat3 protein, rat; EC 3.6.1.-/Transducin
Comments/Corrections

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