Document Detail


Taste-independent detection of the caloric content of sugar in Drosophila.
MedLine Citation:
PMID:  21709242     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Feeding behavior is influenced primarily by two factors: nutritional needs and food palatability. However, the role of food deprivation and metabolic needs in the selection of appropriate food is poorly understood. Here, we show that the fruit fly, Drosophila melanogaster, selects calorie-rich foods following prolonged food deprivation in the absence of taste-receptor signaling. Flies mutant for the sugar receptors Gr5a and Gr64a cannot detect the taste of sugar, but still consumed sugar over plain agar after 15 h of starvation. Similarly, pox-neuro mutants that are insensitive to the taste of sugar preferentially consumed sugar over plain agar upon starvation. Moreover, when given a choice between metabolizable sugar (sucrose or D-glucose) and nonmetabolizable (zero-calorie) sugar (sucralose or L-glucose), starved Gr5a; Gr64a double mutants preferred metabolizable sugars. These findings suggest the existence of a taste-independent metabolic sensor that functions in food selection. The preference for calorie-rich food correlates with a decrease in the two main hemolymph sugars, trehalose and glucose, and in glycogen stores, indicating that this sensor is triggered when the internal energy sources are depleted. Thus, the need to replenish depleted energy stores during periods of starvation may be met through the activity of a taste-independent metabolic sensing pathway.
Authors:
Monica Dus; SooHong Min; Alex C Keene; Ga Young Lee; Greg S B Suh
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-27
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2011-09-20     Revised Date:  2013-07-24    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11644-9     Citation Subset:  IM    
Affiliation:
Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Metabolism
Dietary Sucrose
Drosophila Proteins / genetics,  physiology
Drosophila melanogaster / genetics,  physiology*
Energy Intake
Feeding Behavior / physiology
Food Deprivation / physiology
Food Preferences / physiology
Genes, Insect
Hemolymph / metabolism
Male
Mutation
Receptors, Cell Surface / genetics,  physiology
Starvation / genetics,  physiopathology
Sucrose
Taste / physiology
Grant Support
ID/Acronym/Agency:
1R01GM089746/GM/NIGMS NIH HHS; 5F32GM086207/GM/NIGMS NIH HHS; F32 GM086207-03/GM/NIGMS NIH HHS; R01 DC012791/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Sucrose; 0/Drosophila Proteins; 0/Receptors, Cell Surface; 0/gustatory receptor, Drosophila; 57-50-1/Sucrose
Comments/Corrections

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