| Taste coding in the nucleus of the solitary tract of the awake, freely licking rat. | |
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MedLine Citation:
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PMID: 22855799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is becoming increasingly clear that the brain processes sensory stimuli differently according to whether they are passively or actively acquired, and these differences can be seen early in the sensory pathway. In the nucleus of the solitary tract (NTS), the first relay in the central gustatory neuraxis, a rich variety of sensory inputs generated by active licking converge. Here, we show that taste responses in the NTS reflect these interactions. Experiments consisted of recordings of taste-related activity in the NTS of awake rats as they freely licked exemplars of the five basic taste qualities (sweet, sour, salty, bitter, umami). Nearly all taste-responsive cells were broadly tuned across taste qualities. A subset responded to taste with long latencies (>1.0 s), suggesting the activation of extraoral chemoreceptors. Analyses of the temporal characteristics of taste responses showed that spike timing conveyed significantly more information than spike count alone in almost one-half of NTS cells, as in anesthetized rats, but with less information per cell. In addition to taste-responsive cells, the NTS contains cells that synchronize with licks. Since the lick pattern per se can convey information, these cells may collaborate with taste-responsive cells to identify taste quality. Other cells become silent during licking. These latter "antilick" cells show a surge in firing rate predicting the beginning and signaling the end of a lick bout. Collectively, the data reveal a complex array of cell types in the NTS, only a portion of which include taste-responsive cells, which work together to acquire sensory information. |
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Authors:
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Andre T Roussin; Alexandra E D'Agostino; Andrew M Fooden; Jonathan D Victor; Patricia M Di Lorenzo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-02 Completed Date: 2012-10-15 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 10494-506 Citation Subset: IM |
Affiliation:
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Department of Psychology, Binghamton University, Binghamton, New York 13902, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Animals Citric Acid / pharmacology Dose-Response Relationship, Drug Drinking Behavior / physiology* Male Neural Inhibition / physiology Neurons / drug effects, physiology* Quinine / pharmacology Rats Rats, Sprague-Dawley Reaction Time / physiology Reinforcement (Psychology) Reinforcement Schedule Sodium Chloride / pharmacology Solitary Nucleus / cytology, physiology* Sucrose / pharmacology Sweetening Agents / pharmacology Taste / drug effects, physiology* Wakefulness* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC006914/DC/NIDCD NIH HHS; R01 DC006914/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sweetening Agents; 130-95-0/Quinine; 57-50-1/Sucrose; 7647-14-5/Sodium Chloride; 77-92-9/Citric Acid |
| Comments/Corrections | |
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