Document Detail


Taste solution consumption by FHH-Chr nBN consomic rats.
MedLine Citation:
PMID:  20478838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There has been extensive work to elucidate the behavioral and physiological mechanisms responsible for taste preferences of the rat but little attempt to delineate the underlying genetic architecture. Here, we exploit the FHH-Chr n(BN)/Mcwi consomic rat strain set to identify chromosomes carrying genes responsible for taste preferences. We screened the parental Fawn Hooded Hypertensive (FHH) and Brown Norway (BN) strains and 22 FHH-Chr n(BN) consomic strains, with 96-h 2-bottle tests, involving a choice between water and each of the following 16 solutions: 10 mM NaCl, 237 mM NaCl, 32 mM CaCl(2), 1 mM saccharin, 100 mM NH(4)Cl, 32 mM sucrose, 100 mM KCl, 4% ethanol, 1 mM HCl, 10 mM monosodium glutamate, 1 mM citric acid, 32 microM quinine hydrochloride, 1% corn oil, 32 microM denatonium, 1% Polycose, and 1 microM capsaicin. Depending on the taste solution involved, between 1 and 16 chromosomes were implicated in the response. Few of these chromosomes carried genes believed to mediate taste transduction in the mouse, and many chromosomes with no candidate taste genes were revealed. The genetic architecture of taste preferences is considerably more complex than has heretofore been acknowledged.
Authors:
Michael G Tordoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-05-16
Journal Detail:
Title:  Chemical senses     Volume:  35     ISSN:  1464-3553     ISO Abbreviation:  Chem. Senses     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-09-16     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  473-89     Citation Subset:  IM    
Affiliation:
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. tordoff@monell.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Chromosomes, Mammalian
Data Interpretation, Statistical
Drinking
Rats
Rats, Inbred Strains
Taste / genetics*,  physiology
Taste Perception
Grant Support
ID/Acronym/Agency:
DC-10149/DC/NIDCD NIH HHS; DK-46791/DK/NIDDK NIH HHS
Comments/Corrections

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