| Taste preference for fatty acids is mediated by GPR40 and GPR120. | |
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MedLine Citation:
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PMID: 20573884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The oral perception of fat has traditionally been considered to rely mainly on texture and olfaction, but recent findings suggest that taste may also play a role in the detection of long chain fatty acids. The two G-protein coupled receptors GPR40 (Ffar1) and GPR120 are activated by medium and long chain fatty acids. Here we show that GPR120 and GPR40 are expressed in the taste buds, mainly in type II and type I cells, respectively. Compared with wild-type mice, male and female GPR120 knock-out and GPR40 knock-out mice show a diminished preference for linoleic acid and oleic acid, and diminished taste nerve responses to several fatty acids. These results show that GPR40 and GPR120 mediate the taste of fatty acids. |
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Authors:
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Cristina Cartoni; Keiko Yasumatsu; Tadahiro Ohkuri; Noriatsu Shigemura; Ryusuke Yoshida; Nicolas Godinot; Johannes le Coutre; Yuzo Ninomiya; Sami Damak |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 30 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-07-15 Revised Date: 2011-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 8376-82 Citation Subset: IM |
Affiliation:
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Nestlé Research Center, Lausanne 1000, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acids* Female Food Preferences / physiology* Immunohistochemistry Male Mice Mice, Knockout Receptors, G-Protein-Coupled / genetics, metabolism* Taste / physiology* Taste Buds / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Gpr40 protein, mouse; 0/O3far1 protein, mouse; 0/Receptors, G-Protein-Coupled |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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