| Targets of selection in the Thoroughbred genome contain exercise-relevant gene SNPs associated with elite racecourse performance. | |
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MedLine Citation:
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PMID: 21070277 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Athletic performance is influenced by a complex interplay among the environment and a suite of genes, which contributes to system-wide structure and function. In a panel of elite and non-elite Thoroughbred horses (n=148), we genotyped 68 SNPs in 17 putative exercise-relevant genes chosen from a genome scan for selection. We performed a series of case-control and quantitative association tests for relationships with racecourse performance. Thirteen SNPs in nine genes were significantly (P<0.05) associated with a performance phenotype. We selected five SNPs in four genes (ACSS1, ACN9, COX4I1, PDK4) for validation in an independent sample set of elite and non-elite Thoroughbreds (n=130). Two SNPs in the PDK4 gene were validated (P<0.01) for associations with elite racing performance. When all samples were considered together (n=278), the PDK4_ 38973231 SNP was strongly associated (P<0.0005) with elite racing performance. Individuals with the A:A and A:G genotypes had a 16.2-16.6 lb advantage over G:G individuals in terms of handicap rating. Re-sequencing of the PDK4 gene and further genotyping will be required to identify the causative variant that is likely influencing exercise-induced variation in expression of the gene. Notwithstanding, this information may be employed as a marker for the selection of racehorses with the genetic potential for superior racing ability. |
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Authors:
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E W Hill; J Gu; B A McGivney; D E MacHugh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Animal genetics Volume: 41 Suppl 2 ISSN: 1365-2052 ISO Abbreviation: Anim. Genet. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605704 Medline TA: Anim Genet Country: England |
Other Details:
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Languages: eng Pagination: 56-63 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors, Journal compilation © 2010 Stichting International Foundation for Animal Genetics. |
Affiliation:
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Animal Genomics Laboratory, UCD School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. emmeline.hill@ucd.ie |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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