| Targets for current pharmacologic therapy in cholesterol gallstone disease. | |
| | |
MedLine Citation:
|
PMID: 20478485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Gallstone disease is a frequent condition throughout the world and, cholesterol stones are the most frequent form in Western countries. The standard treatment of symptomatic gallstone subjects is laparoscopic cholecystectomy. The selection of patients amenable for nonsurgical, medical therapy is of key importance; a careful analysis should consider the natural history of the disease and the overall costs of therapy. Only patients with mild symptoms and small, uncalcified cholesterol gallstones in a functioning gallbladder with a patent cystic duct are considered for oral litholysis by hydrophilic ursodeoxycholic acid, in the hope of achieving cholesterol desaturation of bile and progressive stone dissolution. Recent studies have raised the possibility that cholesterol-lowering agents that inhibit hepatic cholesterol synthesis (statins) or intestinal cholesterol absorption (ezetimibe), or drugs acting on specific nuclear receptors involved in cholesterol and bile acid homeostasis, may offer, alone or in combination, additional medical therapeutic tools for treating cholesterol gallstones. Recent perspectives on medical treatment of cholesterol gallstone disease are discussed in this article. |
| | |
Authors:
|
Agostino Di Ciaula; David Q H Wang; Helen H Wang; Leonilde Bonfrate; Piero Portincasa |
Related Documents
:
|
16546125 - The production of oxysterols in bile by activated human leukocytes. 2026335 - Effect of diets low and high in refined sugars on gut transit, bile acid metabolism, an... 2079365 - Effect of oryzanol on cholesterol absorption & biliary & fecal bile acids in rats. 10604575 - Lipid solubilization in human gallbladder versus hepatic biles. 7190135 - Antiobesity activity of pluronic l-101. 19620165 - Cholesterol control beyond the clinic: new york city's trans fat restriction. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Gastroenterology clinics of North America Volume: 39 ISSN: 1558-1942 ISO Abbreviation: Gastroenterol. Clin. North Am. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-18 Completed Date: 2010-10-12 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8706257 Medline TA: Gastroenterol Clin North Am Country: United States |
Other Details:
|
Languages: eng Pagination: 245-64, viii-ix Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Internal Medicine, Hospital of Bisceglie, Bisceglie (Bari), Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Azetidines
/
therapeutic use* Cholesterol / metabolism* Cholinergic Antagonists / therapeutic use* Gallstones / drug therapy*, metabolism Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Intestinal Absorption / drug effects* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
DK54012/DK/NIDDK NIH HHS; DK73917/DK/NIDDK NIH HHS; R01 DK054012-11/DK/NIDDK NIH HHS; R01 DK073917-03/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Azetidines; 0/Cholinergic Antagonists; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 163222-33-1/ezetimibe; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical treatment of gallstones.
Next Document: Gallbladder imaging.