| Targeting the tumour vasculature: insights from physiological angiogenesis. | |
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MedLine Citation:
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PMID: 20574450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiovascular system ensures the delivery of nutrients, oxygen, and blood and immune cells to all organs and tissues: it is also responsible for the removal of waste metabolites. The vascular system develops and matures through two tightly regulated processes: vasculogenesis and angiogenesis. Angiogenesis is active only under specific physiological conditions in healthy adults but the vasculature can be aberrantly activated to generate new blood vessels during pathological conditions such as cancer and chronic inflammation. In this Opinion article we discuss the parallels and differences in the angiogenic process under either a physiological or a pathological state, especially tumorigenesis. |
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Authors:
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Alicia S Chung; John Lee; Napoleone Ferrara |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nature reviews. Cancer Volume: 10 ISSN: 1474-1768 ISO Abbreviation: Nat. Rev. Cancer Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124168 Medline TA: Nat Rev Cancer Country: England |
Other Details:
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Languages: eng Pagination: 505-14 Citation Subset: IM |
Affiliation:
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Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Neoplasms / blood supply*, pathology Neovascularization, Pathologic / drug therapy* Neovascularization, Physiologic* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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