Document Detail


Targeting tumour cells at the entrance.
MedLine Citation:
PMID:  21954944     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Metabolism in tumour cells is adapted to the demands of a growing cell. The Warburg effect and increased use of glutamine are two well-known adaptations of tumour metabolism. Both require transporters to allow uptake of substrates and efflux of products. Differentiated cells are less reliant on these pathways and as a result are less vulnerable to drugs that curtail nutrient uptake. Thus drugs that reduce nutrient uptake are promising candidates for tumour therapy. Detailed understanding of tumour cell biology will allow the generation of new chemotherapeutic drugs with limited side effects.
Authors:
Stefan Bröer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  439     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  e1-2     Citation Subset:  IM    
Affiliation:
Research School of Biology, Australian National University, Canberra, ACT 0200, Australia.
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