Document Detail

Targeting tumour cells at the entrance.
MedLine Citation:
PMID:  21954944     Owner:  NLM     Status:  In-Data-Review    
Metabolism in tumour cells is adapted to the demands of a growing cell. The Warburg effect and increased use of glutamine are two well-known adaptations of tumour metabolism. Both require transporters to allow uptake of substrates and efflux of products. Differentiated cells are less reliant on these pathways and as a result are less vulnerable to drugs that curtail nutrient uptake. Thus drugs that reduce nutrient uptake are promising candidates for tumour therapy. Detailed understanding of tumour cell biology will allow the generation of new chemotherapeutic drugs with limited side effects.
Stefan Bröer
Related Documents :
18241124 - Serum-free differentiation of murine embryonic stem cells into alveolar type ii epithel...
2782394 - Flow cytometric identification and isolation of hypertrophic type ii pneumocytes after ...
12057904 - Increased localization and substrate activation of protein kinase c delta in lung epith...
225274 - Metabolic and functional characteristics of alveolar macrophages recovered from rats ex...
2418184 - Pulmonary blastoma, carcinosarcoma and spindle-cell carcinoma: an immunohistochemical s...
21438584 - Briarane diterpenes diminish cox-2 expression in human colon adenocarcinoma cells.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  439     ISSN:  1470-8728     ISO Abbreviation:  Biochem. J.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  e1-2     Citation Subset:  IM    
Research School of Biology, Australian National University, Canberra, ACT 0200, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  PDZ domains: the building blocks regulating tumorigenesis.
Next Document:  Biological interactions of graphene-family nanomaterials: an interdisciplinary review.