| Targeting of streptococci by zoocin A. | |
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MedLine Citation:
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PMID: 17319876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Zoocin A is a domain-structured peptidoglycan hydrolase produced by Streptococcus equi ssp. zooepidemicus 4881. [(14)C]-zoocin A was used to measure the amount of zoocin A bound to the surface of cells and to purified peptidoglycan. The sensitivity of various streptococci to zoocin A correlated with the amount of zoocin A bound (R(2)=0.8609). Peptidoglycan purified from Streptococcus oralis and Streptococcus rattus were able to bind zoocin A but remained resistant to hydrolysis. All Streptococcus pyogenes strains were extremely sensitive to zoocin A with minimum inhibition concentrations of 31.5 ng mL(-1) or less, suggesting that zoocin A may have potential for use as an enzybiotic. |
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Authors:
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Maria Akesson; Muriel Dufour; Gary L Sloan; Robin S Simmonds |
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Publication Detail:
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Type: Journal Article Date: 2007-02-22 |
Journal Detail:
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Title: FEMS microbiology letters Volume: 270 ISSN: 0378-1097 ISO Abbreviation: FEMS Microbiol. Lett. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-18 Completed Date: 2007-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705721 Medline TA: FEMS Microbiol Lett Country: England |
Other Details:
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Languages: eng Pagination: 155-61 Citation Subset: IM |
Affiliation:
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The Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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metabolism,
pharmacology* Bacteriocins / metabolism, pharmacology Carbon Radioisotopes Microbial Sensitivity Tests Peptidoglycan / metabolism Protein Binding Streptococcus / drug effects, metabolism* Streptococcus equi / drug effects, metabolism* Streptococcus pyogenes / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Bacteriocins; 0/Carbon Radioisotopes; 0/Peptidoglycan; 0/ZooA protein, Streptococcus equi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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