| Targeting the peroxisome proliferator-activated receptors (PPARs) in spinal cord injury. | |
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MedLine Citation:
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PMID: 21740108 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: Traumatic spinal cord injury (SCI) causes severe and permanent functional deficits, due to the primary mechanical insult, followed by secondary tissue degeneration. The direct damage is followed by a second phase of tissue degeneration, which may take place over a period of weeks or even months, causing neuronal and axonal destruction. A key mediator of this process is an acute and robust inflammatory response, which involves the synthesis and release of chemokines and cytokines, and a coordinated recruitment of circulating leucocytes, as well as microglia, from the CNS parenchyma. The search for a 'cure' for SCI has yet to produce a convincingly efficacious treatment that improves the outcome for patients. Areas covered: This review explores the experimental studies describing the beneficial effects of PPAR receptor modulators in spinal cord trauma. Expert opinion: Because of safety issues and limited data, PPAR agonists are not yet included in SCI-related treatment strategies. PPAR agonists for specific isoforms (α, β/δ and γ) have demonstrated both anti-inflammatory and immunomodulatory properties. Pharmacological activation of PPAR can be considered as a multi-faceted therapeutic target, due to its anti-inflammatory/antioxidant/anti-excitotoxic/pro-energetic profile, reported in some neurological and inflammatory-related diseases. |
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Authors:
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Emanuela Esposito; Salvatore Cuzzocrea |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on therapeutic targets Volume: 15 ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: England |
Other Details:
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Languages: eng Pagination: 943-59 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine , University of Messina, via Consolare Valeria, Gazzi, 98125 , Messina Italy +39 090 2213644 ; +39 090 2213300 ; salvator@unime.it. |
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