| Targeting mucosal healing in Crohn's disease. | |
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MedLine Citation:
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PMID: 21869869 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The goal of medical treatment for Crohn's disease includes improving patients' quality of life while reducing the need for hospitalization and surgery. The current medical armamentarium includes 5-aminosalicylates, corticosteroids, immunomodulators, and biologic agents. In the past, response to treatment was measured by clinical improvement in symptoms; however, with the advent of disease-modifying medications, mucosal healing has emerged as an increasingly important goal of therapy. Mucosal healing, or endoscopic remission, is associated with increased rates of clinical remission, fewer hospitalizations, and fewer abdominal surgeries. Both the immunomodulator and biologic classes of medications are effective at inducing mucosal healing. Despite several limitations, mucosal healing has become a desirable and valid measure of disease activity. |
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Authors:
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Aarti Kakkar; Sharmeel K Wasan; Francis A Farraye |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology & hepatology Volume: 7 ISSN: 1554-7914 ISO Abbreviation: Gastroenterol Hepatol (N Y) Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-08-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262648 Medline TA: Gastroenterol Hepatol (N Y) Country: United States |
Other Details:
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Languages: eng Pagination: 374-80 Citation Subset: - |
Affiliation:
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Dr. Kakkar is a Fellow in Gastroenterology, Dr. Wasan is a Clinical Instructor of Medicine, and Dr. Farraye is a Professor of Medicine and Clinical Director of the Section of Gastroenterology at Boston University School of Medicine in Boston, Massachusetts. Drs. Kakkar, Wasan, and Farraye are also affiliated with the Section of Gastroenterology at Boston Medical Center in Boston, Massachusetts. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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