| Targeting motifs in GLUT4 (review). | |
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MedLine Citation:
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PMID: 11780754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The trafficking of the insulin-sensitive glucose transporter, GLUT4, is the paradigm of how cells control the movement of membrane proteins through intricate pathways of transport in response to external stimuli, and how, by doing so, regulate their function. The GLUT4 intracellularly sequestered in resting adipocytes and muscle cells becomes exposed on their surface in response to an increase in insulin levels and muscle contraction, where it facilitates glucose uptake. Ceasing of the stimuli is followed by endocytosis of the GLUT4 molecules exposed on the plasma membrane and their recycling to the original stores, where they are retained. This review discusses current understanding of the organelles that host GLUT4 and the motifs that mediate its trafficking. |
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Authors:
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V Lalioti; S Vergarajauregui; I V Sandoval |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Molecular membrane biology Volume: 18 ISSN: 0968-7688 ISO Abbreviation: Mol. Membr. Biol. Publication Date: 2001 Oct-Dec |
Date Detail:
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Created Date: 2002-01-08 Completed Date: 2002-07-12 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9430797 Medline TA: Mol Membr Biol Country: England |
Other Details:
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Languages: eng Pagination: 257-64 Citation Subset: IM |
Affiliation:
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Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism Amino Acid Motifs Animals Cell Membrane / metabolism Endocytosis Endosomes / metabolism Glucose / metabolism Glucose Transporter Type 4 Humans Insulin / metabolism Lysosomes / metabolism Models, Biological Monosaccharide Transport Proteins / chemistry*, metabolism* Muscle Proteins* Muscle, Skeletal / metabolism Protein Sorting Signals Protein Structure, Tertiary trans-Golgi Network / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glucose Transporter Type 4; 0/Monosaccharide Transport Proteins; 0/Muscle Proteins; 0/Protein Sorting Signals; 0/SLC2A4 protein, human; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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