| Targeting the ischemic penumbra. | |
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MedLine Citation:
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PMID: 21164112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the last 3 decades, and from a therapeutic point of view, the classical concept of ischemic penumbra based on hemodynamic and electrophysiological parameters has loosened up the rigidity of therapeutic windows in acute stroke management. Thirty years later, the ischemic penumbra is an evolved concept that presents more applications. Thus, the ischemic penumbra is a diagnostic target, allowing the extension of therapeutic windows; it is also a biochemical target, in which an intermittent bioenergetic compromise takes place, and it is a target for brain plasticity, neuroprotection, and neurorepair. SUMMARY OF REVIEW: In this work, we review how the concept of ischemic penumbra has been evolving from its purely electrophysiological/ hemodynamic based definition to the wider metabolic-cellular-therapeutic concept that is managed today by neuroscientists. |
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Authors:
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Pedro Ramos-Cabrer; Francisco Campos; Tomás Sobrino; José Castillo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-12-16 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 42 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-28 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: S7-11 Citation Subset: IM |
Affiliation:
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Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario de Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Ischemia Electrophysiological Phenomena Hemodynamics* Stroke* / metabolism, pathology, physiopathology, therapy Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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