Document Detail


Targeting of heme oxygenase inhibitors to the spleen markedly increases their ability to diminish bilirubin production.
MedLine Citation:
PMID:  2587139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Incorporation of heme oxygenase inhibitors into phosphatidyl choline liposomes markedly enhanced localization of these agents within the spleen as compared with the localization observed following their administration in aqueous vehicle. The increased concentration of inhibitor within splenic microsomes led to a near complete and sustained blockade of heme oxygenase activity and thus to a marked diminution in biliary bilirubin output. These studies suggest that heme oxygenase inhibitors administered within liposomes may so effectively block bilirubin production in the human newborn that ancillary methods for treating this important clinical problem may be reduced to a minimum.
Authors:
S A Landaw; G S Drummond; A Kappas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  84     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1989-12-27     Completed Date:  1989-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1091-6     Citation Subset:  AIM; IM    
Affiliation:
Rockefeller University Hospital, New York, NY 10021.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bilirubin / biosynthesis*
Drug Carriers
Heme Oxygenase (Decyclizing) / antagonists & inhibitors*
Liposomes
Liver / analysis,  enzymology
Male
Metalloporphyrins / administration & dosage*,  pharmacokinetics
Mixed Function Oxygenases / antagonists & inhibitors*
Porphyrins / administration & dosage*
Protoporphyrins / administration & dosage*,  pharmacokinetics
Rats
Rats, Inbred Strains
Spleen / analysis,  enzymology,  metabolism*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Liposomes; 0/Metalloporphyrins; 0/Porphyrins; 0/Protoporphyrins; 106344-20-1/tin mesoporphyrin; 14325-05-4/tin protoporphyrin IX; 635-65-4/Bilirubin; EC 1.-/Mixed Function Oxygenases; EC 1.14.99.3/Heme Oxygenase (Decyclizing)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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