| Targeting the ghrelin receptor to regulate food intake. | |
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MedLine Citation:
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PMID: 19362579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increasing prevalence of obesity and the obesity-associated morbidities represent one of the major health problems of the western society. This has renewed interest in our understanding of factors that control appetite. The 28 amino acid peptide may represent one of the key players in the regulation of food intake since it is the only circulating orexigenic peptide. Ghrelin not only acts as a hunger signal but also as an adiposity signal. These effects are influenced by the internal energy status and can be considered as homeostatic signals. In addition ghrelin has direct effects on components of the reward system and increases the appetitive value of food. This hedonic feeding behavior of ghrelin can be considered as a non-homeostatic signal as it occurs in the absence of nutritional or caloric deficiency. In this review we address how these signals, elicited by ghrelin, can powerfully augment the drive to eat. Better understanding of the mechanisms by which ghrelin exerts its effect may enable the development of new treatments for obesity but also for conditions of cachexia. |
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Authors:
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Inge Depoortere |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-04-10 |
Journal Detail:
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Title: Regulatory peptides Volume: 156 ISSN: 1873-1686 ISO Abbreviation: Regul. Pept. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: Netherlands |
Other Details:
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Languages: eng Pagination: 13-23 Citation Subset: IM |
Affiliation:
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Centre for Gastroenterological Research, Gasthuisberg, O&N, box 701, B-3000 Leuven, Belgium. inge.depoortere@med.kuleuven.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite / drug effects, physiology Eating / drug effects*, physiology* Energy Metabolism / drug effects, physiology Feeding Behavior / drug effects, physiology Ghrelin / metabolism, physiology Humans Receptors, Ghrelin / agonists*, antagonists & inhibitors*, metabolism, physiology Signal Transduction / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Receptors, Ghrelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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