| Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells. | |
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MedLine Citation:
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PMID: 22704088 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Epigenetic treatment concepts have long been ascribed as being tumour-selective. Over the last decade, it has become evident that epigenetic mechanisms are essential for a wide range of intracellular functions in healthy cells as well. Evaluation of possible side-effects and their underlying mechanisms in healthy human cells is necessary in order to improve not only patient safety, but also to support future drug development. Since epigenetic regulation directly interacts with genomic and chromosomal packaging density, increasing genomic instability may be a result subsequent to drug-induced epigenetic modifications. This review highlights past and current research efforts on the influence of epigenetic modification on genomic stability in healthy human cells. |
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Authors:
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Jan C Purrucker; Ulrich Mahlknecht |
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Publication Detail:
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Type: Journal Article Date: 2010-07-27 |
Journal Detail:
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Title: Clinical epigenetics Volume: 1 ISSN: 1868-7083 ISO Abbreviation: Clin Epigenetics Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2012-06-18 Completed Date: 2012-10-02 Revised Date: 2013-03-05 |
Medline Journal Info:
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Nlm Unique ID: 101516977 Medline TA: Clin Epigenetics Country: Germany |
Other Details:
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Languages: eng Pagination: 45-54 Citation Subset: - |
Affiliation:
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Division of Immunotherapy and Gene Therapy, José Carreras Center for Immunotherapy and Gene Therapy, Department of Internal Medicine, Saarland University Medical Center, 66421 Homburg/Saar, Germany. |
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