Document Detail


Targeting endothelial and tumor cells with semaphorins.
MedLine Citation:
PMID:  17768598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropilins (NRP) are receptors for the class 3 semaphorin (SEMA3) family of axon guidance molecules and the vascular endothelial growth factor (VEGF) family of angiogenesis factors. Although the seminal studies on SEMA3s and NRPs first showed them to be mediators of axon guidance, it has become very apparent that these proteins play an important role in vascular and tumor biology as well. Neuronal guidance and angiogenesis are regulated similarly at the molecular level. For example, SEMA3s not only repel neurons and collapse axon growth cones, but have similar effects on endothelial cells and tumor cells. Preclinical studies indicate that SEMA3F is a potent inhibitor of tumor angiogenesis and metastasis. In addition, neutralizing antibodies to NRP1 enhance the effects of anti-VEGF antibodies in suppressing tumor growth in xenograft models. This article reviews NRP and SEMA3 structural interactions and their role in developmental angiogenesis, tumor angiogenesis and metastasis based on cell culture, zebrafish and murine studies.
Authors:
Diane R Bielenberg; Michael Klagsbrun
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer metastasis reviews     Volume:  26     ISSN:  0167-7659     ISO Abbreviation:  Cancer Metastasis Rev.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605731     Medline TA:  Cancer Metastasis Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  421-31     Citation Subset:  IM    
Affiliation:
Vascular Biology Program, Children's Hospital, Department of Surgery, Harvard Medical School, Karp Family Research Laboratories, 12.211, 300 Longwood Avenue, Boston, MA 02115, USA. diane.bielenberg@childrens.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillary Permeability
Endothelial Cells / physiology*
Humans
Neoplasm Metastasis / prevention & control*
Neovascularization, Pathologic / prevention & control*
Neovascularization, Physiologic*
Neuropilins / chemistry,  physiology*
Semaphorins / chemistry,  physiology*
Signal Transduction
Vascular Endothelial Growth Factor A / physiology
Grant Support
ID/Acronym/Agency:
CA11873/CA/NCI NIH HHS; CA37392/CA/NCI NIH HHS; CA45548/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Neuropilins; 0/Semaphorins; 0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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