Document Detail


Targeting cardiovascular medication adherence interventions.
MedLine Citation:
PMID:  22618980     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVES To determine whether adherence interventions should be administered to all medication takers or targeted to nonadherers. DATA SOURCES AND STUDY SELECTION Systematic search (Medline and Embase, 1966-2009) of randomized controlled trials of interventions to improve adherence to medications for preventing or treating cardiovascular disease or diabetes. DATA EXTRACTION Articles were classified as (1) broad interventions (targeted all medication takers), (2) focused interventions (targeted nonadherers), or (3) dynamic interventions (administered to all medication takers; real-time adherence information targets nonadherers as intervention proceeds). Cohen's d effect sizes were calculated. DATA SYNTHESIS We identified 7,190 articles; 59 met inclusion criteria. Broad interventions were less likely (18%) to show medium or large effects compared with focused (25%) or dynamic (32%) interventions. Of the 33 dynamic interventions, 6 used externally generated adherence data to target nonadherers. Those with externally generated data were less likely to have a medium or large effect (20% vs. 34.8% self-generated data). CONCLUSION Adherence interventions targeting nonadherers are heterogeneous but may have advantages over broad interventions. Dynamic interventions show promise and require further study.
Authors:
Sarah L Cutrona; Niteesh K Choudhry; Michael A Fischer; Amber D Servi; Margaret Stedman; Joshua N Liberman; Troyen A Brennan; William H Shrank
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Pharmacists Association : JAPhA     Volume:  52     ISSN:  1544-3450     ISO Abbreviation:  J Am Pharm Assoc (2003)     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101176252     Medline TA:  J Am Pharm Assoc (2003)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381-97     Citation Subset:  IM    
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