| Targeting apoptosis pathways in childhood malignancies. | |
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MedLine Citation:
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PMID: 21036468 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Evasion of apoptosis (programmed cell death) is a characteristic feature of human cancers including childhood malignancies. Since cytotoxic therapies such as chemotherapy or radiotherapy trigger apoptosis as a primary mechanism of action, resistance to apoptosis can also lead to treatment resistance. Studies on apoptosis pathways in childhood malignancies yielded a series of key molecules that can now be exploited as molecular targets for the development of targeted therapies. This strategy is anticipated to open novel perspectives for more effective treatment options for children with cancer. |
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Authors:
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Simone Fulda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-10-29 |
Journal Detail:
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Title: Cancer letters Volume: - ISSN: 1872-7980 ISO Abbreviation: - Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Komturstr. 3a, 60528 Frankfurt/Main, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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