| Targeting apoptosis pathways by natural compounds in cancer: Marine compounds as lead structures and chemical tools for cancer therapy. | |
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MedLine Citation:
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PMID: 20673697 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Natural compounds derived from marine organisms have shown a wide variety of anti-tumor effects and a lot of attention has been drawn to further development of the isolated compounds. A vast quantity of individual chemical structures from different organisms has shown a variety of apoptosis inducing mechanisms in a variety of tumor cells. The bis-steroidal cephalostatin 1 for example, induces apoptosis via activation of caspases whereas the polyketide discodermolide inhibits cell growth by binding to and stabilizing microtubule and salisporamide A, the product of an actinobacterial strain, is an inhibitor of the proteasome. This great variety of mechanisms of action can help to overcome the multitude of resistances exhibited by different tumor specimens. Products from marine organisms and their synthetic derivates are therefore an important source for new therapeutics for single agent or combined therapy with other chemotherapeutics to support the struggle against cancer. |
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Authors:
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Karin von Schwarzenberg; Angelika M Vollmar |
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Publication Detail:
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Type: Journal Article Date: 2010-07-31 |
Journal Detail:
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Title: Cancer letters Volume: 332 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2013 May |
Date Detail:
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Created Date: 2013-04-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 295-303 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacy, Center for Drug Research, Butenandtstr. 5-11, 81375 Munich, Germany. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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