Document Detail

Targeting angiogenesis to restore the microcirculation after reperfused MI.
MedLine Citation:
PMID:  19528962     Owner:  NLM     Status:  MEDLINE    
Since early reperfusion therapy for patients with acute myocardial infarction (AMI) was demonstrated to decrease mortality, numerous improvements in AMI management have focused on prompt reperfusion of the epicardial coronary arteries. However, in a substantial group of patients with AMI, reperfusion of the myocardial tissue is hindered by dysfunction of the microvasculature, despite successful restoration of the epicardial coronary flow. These patients have prolonged ischemia and an adverse clinical outcome. Although several studies investigating the etiology of microvascular dysfunction have been performed, little is known about the restoration process of microvascular dysfunction after reperfused AMI. The objective of this Review is to summarize our knowledge on natural restoration of the microvasculature after reperfused AMI, particularly with regard to angiogenesis, discuss diagnostic modalities used to identify patients with microvascular dysfunction and highlight the potential of pharmacological and cellular interventions to stimulate the recovery of the microvasculature by promoting angiogenesis.
Anja M van der Laan; Jan J Piek; Niels van Royen
Publication Detail:
Type:  Journal Article; Review     Date:  2009-06-16
Journal Detail:
Title:  Nature reviews. Cardiology     Volume:  6     ISSN:  1759-5010     ISO Abbreviation:  Nat Rev Cardiol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500075     Medline TA:  Nat Rev Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  515-23     Citation Subset:  IM    
Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Artery Disease / physiopathology
Coronary Circulation
Coronary Vessels
Microcirculation / drug effects
Myocardial Infarction / therapy*
Neovascularization, Physiologic / drug effects*,  physiology

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