Document Detail


Targeting wall techoic acid biosynthesis: an in vivo based high-throughput screen for small molecule inhibitors.
MedLine Citation:
PMID:  19888733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Identification of uncommon targets for inhibition, such as virulence factors, represents an emerging approach for combating the problem of antibiotic resistance among bacteria. Unfortunately, the lack of effective systems for the discovery and evaluation of inhibitors for such targets has considerably slowed progress. A recent article in ACS Chemical Biology, however, details the development of an in vivo based high-throughput screening strategy for identification of small molecule inhibitors of wall techoic acid biosynthesis.
Authors:
Wenlan Chen; Robert Woodward; Peng George Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ACS chemical biology     Volume:  4     ISSN:  1554-8937     ISO Abbreviation:  ACS Chem. Biol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282906     Medline TA:  ACS Chem Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  893-4     Citation Subset:  IM    
Affiliation:
Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
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MeSH Terms
Descriptor/Qualifier:
Drug Evaluation, Preclinical
High-Throughput Screening Assays
Small Molecule Libraries / chemistry,  pharmacology*
Staphylococcus aureus / drug effects*,  metabolism*
Teichoic Acids / biosynthesis*
Chemical
Reg. No./Substance:
0/Small Molecule Libraries; 0/Teichoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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