| Targeting wall techoic acid biosynthesis: an in vivo based high-throughput screen for small molecule inhibitors. | |
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MedLine Citation:
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PMID: 19888733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Identification of uncommon targets for inhibition, such as virulence factors, represents an emerging approach for combating the problem of antibiotic resistance among bacteria. Unfortunately, the lack of effective systems for the discovery and evaluation of inhibitors for such targets has considerably slowed progress. A recent article in ACS Chemical Biology, however, details the development of an in vivo based high-throughput screening strategy for identification of small molecule inhibitors of wall techoic acid biosynthesis. |
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Authors:
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Wenlan Chen; Robert Woodward; Peng George Wang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: ACS chemical biology Volume: 4 ISSN: 1554-8937 ISO Abbreviation: ACS Chem. Biol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101282906 Medline TA: ACS Chem Biol Country: United States |
Other Details:
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Languages: eng Pagination: 893-4 Citation Subset: IM |
Affiliation:
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Departments of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio 43210, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Evaluation, Preclinical High-Throughput Screening Assays Small Molecule Libraries / chemistry, pharmacology* Staphylococcus aureus / drug effects*, metabolism* Teichoic Acids / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Small Molecule Libraries; 0/Teichoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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