| Targeting the TNF-alpha pathway in sarcoidosis. | |
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MedLine Citation:
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PMID: 20001207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AREAS COVERED IN THIS REVIEW: TNF-alpha roles in sarcoid inflammation and granuloma formation are reviewed based on the literature published in the last two decades and the therapies able to target it specifically or non-specifically in sarcoidosis are discussed. WHAT THE READER WILL GAIN: A better understanding of the pathogenic role of TNF-alpha in sarcoidosis and of the scientific rationale of its therapeutic blockade. TAKE HOME MESSAGE: In some subsets of sarcoidosis with more rapid progession and/or therapeutic refractoriness TNF-alpha plays a more prominent role in disease pathogenesis, and its blockade might represent an appropriate therapeutic approach. |
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Authors:
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Sabina A Antoniu |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on therapeutic targets Volume: 14 ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-19 Revised Date: 2011-01-11 |
Medline Journal Info:
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Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: England |
Other Details:
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Languages: eng Pagination: 21-9 Citation Subset: IM |
Affiliation:
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Pulmonary Disease University Hospital, 700115 Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Antibodies, Monoclonal / therapeutic use Humans Immunoglobulin G / therapeutic use Pentoxifylline / therapeutic use Receptors, Tumor Necrosis Factor / therapeutic use Sarcoidosis / drug therapy*, pathology Signal Transduction / drug effects Thalidomide / therapeutic use Tumor Necrosis Factor-alpha / antagonists & inhibitors*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 0/adalimumab; 0/infliximab; 185243-69-0/TNFR-Fc fusion protein; 50-35-1/Thalidomide; 6493-05-6/Pentoxifylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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