| Targeting residual risk: the rationale for the use of non-HDL cholesterol. | |
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MedLine Citation:
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PMID: 20375942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is a wealth of epidemiological and clinical data linking low-density lipoprotein cholesterol (LDLc) with atherosclerotic cardiovascular disease. Numerous primary and secondary prevention trials have demonstrated that reduction in LDLc leads to significant decrease in cardiovascular event rates. However, patients continue to be at significant risk for recurrent events despite aggressive LDLc lowering, reflecting a substantial residual risk. Numerous parameters like apolipoprotein B, LDL particle size, number and non-high density lipoprotein cholesterol (non-HDLc) measurement have been used to assess and address this high residual risk. Herein, we discuss the rationale and the evidence supporting the use of non-HDLc. We also discuss therapeutic options and provide a practical approach to residual risk reduction from a primary care perspective. |
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Authors:
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Venkata M Alla; Manu Kaushik; Aryan Mooss |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Southern medical journal Volume: 103 ISSN: 1541-8243 ISO Abbreviation: South. Med. J. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 434-7; quiz 438-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Creighton University Medical Center, Omaha, NE, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
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prevention & control* Cholesterol, HDL / blood Cholesterol, LDL / blood Humans Lipids / blood* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids |
| Comments/Corrections | |
Comment In:
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South Med J. 2010 May;103(5):392-3
[PMID:
20375947
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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