| Targeting the recruitment of monocytes and macrophages in renal disease. | |
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MedLine Citation:
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PMID: 20620675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macrophages convert proinflammatory or anti-inflammatory signals of tissue microenvironments into response mechanisms. These response mechanisms largely derive from evolutionary conserved defense programs of innate host defense, wound healing, and tissue homeostasis. Hence, in many settings these programs lead to renal inflammation and tissue remodeling (ie, glomerulonephritis and sclerosis or interstitial nephritis and fibrosis). There is abundant experimental evidence that blocking macrophage recruitment or macrophage activation can ameliorate renal inflammation and fibrosis. In this review we discuss experimental tools to target renal macrophage recruitment by using antagonists against selectins, chemokines, integrins, or other important cytokines that mediate renal injury via macrophage recruitment, some of these already having been used in clinical trials. |
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Authors:
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Volker Vielhauer; Onkar Kulkarni; Christoph A Reichel; Hans-Joachim Anders |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 30 ISSN: 1558-4488 ISO Abbreviation: Semin. Nephrol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 318-33 Citation Subset: IM |
Affiliation:
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Klinikum der Universität, Ludwig-Maximilians-University, Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemokines / antagonists & inhibitors Cytokines / antagonists & inhibitors Dendritic Cells / drug effects, physiology Forecasting Humans Integrins / antagonists & inhibitors Kidney Diseases / drug therapy*, immunology* Macrophages / drug effects*, physiology* Molecular Targeted Therapy* Monocytes / drug effects*, physiology* Selectins |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Cytokines; 0/Integrins; 0/Selectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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