| Targeting interleukin-21 in immune-mediated pathologies. | |
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MedLine Citation:
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PMID: 20014999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin (IL)-21, a cytokine mostly produced by activated CD4+ T cells, has been reported to play an important role in the tissue-damaging immune response in various organs. This pathogenic effect is strictly linked to the ability of IL-21 to control the functional activities of multiple immune and non-immune cells. For instance, IL-21 regulates the differentiation and function of effector CD4+ T helper cells; controls activation, proliferation, and survival of B cells and enhances the cytotoxic activity of CD8+ T cells and NK cells. IL-21 also inhibits the differentiation of inducible regulatory T cells (Tregs) and makes effector CD4+ T cells resistant to the Tregs-mediated immunesuppression. Additionally, IL-21 stimulates epithelial cells and fibroblasts to make chemokines and extracellular matrix proteases, respectively. Consistently, studies from various laboratories have documented the beneficial effect of IL-21 neutralization on the progression of inflammatory diseases in mice. Here we review the present knowledge on the expression and role of IL-21 in immune-mediated pathologies. |
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Authors:
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Massimiliano Sarra; Francesco Pallone; Thomas T Macdonald; Giovanni Monteleone |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current drug targets Volume: 11 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 645-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Rome "Tor Vergata", Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology Autoimmunity / genetics Disease Models, Animal Drug Delivery Systems / methods* Humans Immune System Diseases / drug therapy*, metabolism Interleukins / antagonists & inhibitors, genetics, metabolism* Polymorphism, Genetic Receptors, Interleukin-21 / genetics |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Interleukins; 0/Receptors, Interleukin-21; 0/interleukin-21 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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