Document Detail


Targeting IL-17 and T(H)17 cells in chronic inflammation.
MedLine Citation:
PMID:  23023676     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The key role of interleukin-17 (IL-17) and T helper 17 (T(H)17) cells in tissue inflammation, autoimmunity and host defence led to the experimental targeting of these molecules in mouse models of diseases as well as in clinical settings. Moreover, the demonstration that IL-17 and T(H)17 cells contribute to local and systemic aspects of disease pathogenesis, as well as the finding that the IL-17-T(H)17 cell pathway is regulated by IL-23, prompted the identification of inhibitors. These inhibitors include biotechnology products that target IL-23 as well as the leading member of the IL-17 family, IL-17A, and one of its receptors, IL-17 receptor A. Several clinical trials of these inhibitors are underway, and positive results have been obtained in psoriasis, rheumatoid arthritis and ankylosing spondylitis. This Review focuses on the current knowledge of the IL-17-T(H)17 cell pathway to better understand the positive as well as potential negative consequences of targeting them.
Authors:
Pierre Miossec; Jay K Kolls
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature reviews. Drug discovery     Volume:  11     ISSN:  1474-1784     ISO Abbreviation:  Nat Rev Drug Discov     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124171     Medline TA:  Nat Rev Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  763-76     Citation Subset:  IM    
Affiliation:
1] Department of Clinical Immunology and Rheumatology, University of Lyon 1, Hôpital Edouard Herriot, 5 Place d'Arsonval, 69437 Lyon, France. [2] Immunogenomics and inflammation research unit EA 4130, University of Lyon 1, Hôpital Edouard Herriot, 5 Place d'Arsonval, 69437 Lyon, France.
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