Document Detail

Targeting IL-1 in Sjögren's syndrome.
MedLine Citation:
PMID:  23320392     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: IL-1 plays key roles in the biological functions of various cells. In particular, many roles of IL-1 in the immune system have been discovered by numerous studies. This review focuses on the association of IL-1 with the pathogenesis of autoimmunity.
AREAS COVERED: An overview of the biological functions of the IL-1 family and the IL-1 receptors (IL-1Rs), including the maintenance of systemic or local homeostasis, and the signaling pathway through IL-1/IL-1R in various immune systems are described. Several functions of IL-1 in the pathogenesis of Sjögren's syndrome (SS) have been demonstrated with a focus on the immune responses and target tissues in SS. In addition to the role of IL-1 in the immune responses in SS, the function of IL-1 in ocular mucosa lesions in SS has been described. Lastly, there is an overview of possible therapeutic strategies for IL-1 inhibition in SS.
EXPERT OPINION: IL-1 plays critical roles in the onset and development of SS by controlling systemic or local immune responses and maintaining the survival and mucosal defense of target epithelial cells. The inhibition of the pathogenic functions of IL-1 may be beneficial for treating SS.
Akiko Yamada; Rieko Arakaki; Yasusei Kudo; Naozumi Ishimaru
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-16
Journal Detail:
Title:  Expert opinion on therapeutic targets     Volume:  17     ISSN:  1744-7631     ISO Abbreviation:  Expert Opin. Ther. Targets     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-08-28     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101127833     Medline TA:  Expert Opin Ther Targets     Country:  England    
Other Details:
Languages:  eng     Pagination:  393-401     Citation Subset:  IM    
Institute of Health Biosciences, Department of Oral Molecular Pathology, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8504, Japan.
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MeSH Terms
Antirheumatic Agents / pharmacology,  therapeutic use*
Interleukin-1 / antagonists & inhibitors*,  metabolism,  secretion
Lacrimal Apparatus / drug effects,  immunology,  metabolism,  secretion
Molecular Targeted Therapy*
Mucous Membrane / drug effects*,  immunology,  metabolism,  secretion
Protein Isoforms / antagonists & inhibitors,  metabolism,  secretion
Receptors, Interleukin-1 / antagonists & inhibitors*,  metabolism
Salivary Glands / drug effects,  immunology,  metabolism,  secretion
Signal Transduction / drug effects
Sjogren's Syndrome / drug therapy*,  immunology,  metabolism
Reg. No./Substance:
0/Antirheumatic Agents; 0/Interleukin-1; 0/Protein Isoforms; 0/Receptors, Interleukin-1

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