Document Detail

Targeting the fibroblast growth factor receptors for the treatment of cancer.
MedLine Citation:
PMID:  23272905     Owner:  NLM     Status:  MEDLINE    
Receptor tyrosine kinases (RTKs) are transmembrane proteins that play a critical role in stimulating signal transduction cascades to influence cell proliferation, growth, and differentiation and they have also been shown to promote angiogenesis when they are up-regulated or mutated. For this reason, their dysfunction has been implicated in the development of human cancer. Over the past decade, much attention has been devoted to developing inhibitors and antibodies against several classes of RTKs, including vascular endothelial growth factor receptors (VEGFRs), epidermal growth factor receptors (EGFRs), and platelet-derived growth factor receptors (PDGFRs). More recently, interest in the fibroblast growth factor receptor (FGFR) class of RTKs as a drug target for the treatment of cancer has emerged. Signaling through FGFRs is critical for normal cellular function and their dysregulation has been linked to various malignancies such as breast and prostate cancer. This review will focus on the current state of both small molecules and antibodies as FGFR inhibitors to provide insight into their development and future potential as anti-cancer agents.
Steven M Lemieux; M Kyle Hadden
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anti-cancer agents in medicinal chemistry     Volume:  13     ISSN:  1875-5992     ISO Abbreviation:  Anticancer Agents Med Chem     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-31     Completed Date:  2014-02-03     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  101265649     Medline TA:  Anticancer Agents Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  748-61     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / administration & dosage*,  chemistry,  metabolism
Clinical Trials as Topic / methods
Drug Delivery Systems / methods*,  trends
Neoplasms / drug therapy*,  metabolism*
Receptors, Fibroblast Growth Factor / antagonists & inhibitors*,  metabolism
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents; 0/Receptors, Fibroblast Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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