| Targeting Eosinophil's Biology in Asthma Therapy. | |
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MedLine Citation:
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PMID: 21474432 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Due to their role as main effector cells in immune reactions against invading parasites, eosinophils have a plethora of molecules available to destroy these complex pathogens. Their role in allergic diseases such as bronchial asthma, where these do not have to controvert pathogens, is discussed controversially. However, ever since eosinophils have been identified by Paul Ehrlich in tissue and sputum of asthma patients, it was regarded that their important defensive role turns into its direct opposite so that these cells cause destruction of the airway tissue ultimately leading to the formation of disease phenotype. Thus, eosinophils were identified as a prime target in therapeutic intervention of bronchial asthma. Over the last years a number of mediators and receptors involved in the regulation of eosinophil recruitment, chemotaxis, activation, survival, and apoptosis have been identified. Some of these molecules have been addressed in-vitro and in animal models of experimental asthma to evaluate their therapeutic potential in asthma. Furthermore, the therapeutic potential of a few of these candidates has been evaluated in clinical studies, which produced quite perplexing results that even questioned the role of eosinophils in asthma pathogenesis. This article aims at summarizing these approaches and gives a critical overview about further candidate molecules that are recently discussed as targets for an eosinophil specific asthma therapy. |
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Authors:
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Michael Wegmann |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-7 |
Journal Detail:
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Title: American journal of respiratory cell and molecular biology Volume: - ISSN: 1535-4989 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dept. of Experimental Pneumology, Research Center Borstel, Parkallee 1-40, Borstel, 23845, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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