Document Detail


Targeting Dendritic Cells in vivo for Cancer Therapy.
MedLine Citation:
PMID:  22566899     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Monoclonal antibodies that recognize cell surface molecules have been used deliver antigenic cargo to dendritic cells (DC) for induction of immune responses. The encouraging anti-tumor immunity elicited using this immunization strategy suggests its suitability for clinical trials. This review discusses the complex network of DC, the functional specialization of DC subsets, the immunological outcomes of targeting different DC subsets and their cell surface receptors, and the requirements for the induction of effective anti-tumor CD4 and CD8 T cell responses that can recognize tumor-specific antigens. Finally, we review preclinical experiments and the progress toward targeting human DC in vivo.
Authors:
Irina Caminschi; Eugene Maraskovsky; William Ross Heath
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Publication Detail:
Type:  Journal Article     Date:  2012-02-07
Journal Detail:
Title:  Frontiers in immunology     Volume:  3     ISSN:  1664-3224     ISO Abbreviation:  Front Immunol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101560960     Medline TA:  Front Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  13     Citation Subset:  -    
Affiliation:
Immunology Division, The Walter and Eliza Hall Institute of Medical Research Melbourne, VIC, Australia.
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