| Targeting DHFR in parasitic protozoa. | |
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MedLine Citation:
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PMID: 15718161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parasitic apicomplexans are responsible for some of the most severe worldwide health problems, including malaria, toxoplasmosis and cryptosporidiosis. These parasites are characterized by a bifunctional enzyme, dihydrofolate reductase-thymidylate synthase (DHFR-TS), which has a crucial role in pyrimidine biosynthesis. Inhibitors of DHFR have been successful in the treatment of toxoplasmosis and malaria. However, there is currently no effective therapy for cryptosporidiosis, and despite early successes against malaria, resistance to DHFR inhibitors in malaria parasites has now become a global problem. Novel DHFR inhibitors, designed using the recently revealed crystal structures of the enzymes from two parasitic protozoa, are in development. |
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Authors:
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Amy C Anderson |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drug discovery today Volume: 10 ISSN: 1359-6446 ISO Abbreviation: Drug Discov. Today Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-02-18 Completed Date: 2005-09-01 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9604391 Medline TA: Drug Discov Today Country: England |
Other Details:
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Languages: eng Pagination: 121-8 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. Amy.C.Anderson@Dartmouth.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiprotozoal Agents / pharmacology*, therapeutic use Clinical Trials as Topic Eukaryota / drug effects*, enzymology, physiology Folic Acid Antagonists / pharmacology*, therapeutic use Humans Protozoan Infections / drug therapy*, enzymology Tetrahydrofolate Dehydrogenase / chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents; 0/Folic Acid Antagonists; EC 1.5.1.3/Tetrahydrofolate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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