| Targeting the "Cytokine Storm" for therapeutic benefit. | |
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MedLine Citation:
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PMID: 23283640 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inflammation is the body's first line of defence against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens such as the Influenza virus and the Gram negative bacterium Francisella tularensis, do trigger life-threatening cytokine storms in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that down-regulating inflammatory immune responses may improve outcome. We review some of the current candidates for treatment of cytokine storms which may prove useful in the clinic in the future, and compare them to more traditional therapeutic candidates that target the pathogen rather than the host response. |
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Authors:
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Riccardo V D'Elia; Kate Harrison; Petra C Oyston; Roman A Lukaszewski; Graeme C Clark |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-2 |
Journal Detail:
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Title: Clinical and vaccine immunology : CVI Volume: - ISSN: 1556-679X ISO Abbreviation: Clin. Vaccine Immunol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101252125 Medline TA: Clin Vaccine Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Biomedical Sciences, Dstl Porton Down, Salisbury, SP4 0JQ, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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