Document Detail

Targeting the "cytokine storm" for therapeutic benefit.
MedLine Citation:
PMID:  23283640     Owner:  NLM     Status:  MEDLINE    
Inflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacterium Francisella tularensis, do trigger life-threatening "cytokine storms" in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We review some of the current candidates for treatment of cytokine storms which may prove useful in the clinic in the future and compare them to more traditional therapeutic candidates that target the pathogen rather than the host response.
Riccardo V D'Elia; Kate Harrison; Petra C Oyston; Roman A Lukaszewski; Graeme C Clark
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-02
Journal Detail:
Title:  Clinical and vaccine immunology : CVI     Volume:  20     ISSN:  1556-679X     ISO Abbreviation:  Clin. Vaccine Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-19     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  101252125     Medline TA:  Clin Vaccine Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-27     Citation Subset:  IM    
Biomedical Sciences, Dstl Porton Down, Salisbury, United Kingdom.
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MeSH Terms
Communicable Diseases / immunology*,  pathology*
Cytokines / antagonists & inhibitors*,  immunology*
Immunologic Factors / therapeutic use*
Reg. No./Substance:
0/Cytokines; 0/Immunologic Factors

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