| Targeting IKK/NF-κB pathway reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats. | |
| | |
MedLine Citation:
|
PMID: 22289688 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
IKK/NF-κB pathway is a principal player in the regulation of inflammation and apoptosis in spinal cord injury (SCI). We have previously shown that BMS-345541, a selective inhibitor of IKK, could inhibit NF-κB activation and ameliorate the motor function of hind limbs in rats after SCI. However its neuroprotective mechanism in SCI is still unclear. In this study, we investigated the neuroprotective effects of BMS-345541 and possible mechanisms by which BMS-345541 acts against inflammatory cells infiltration and apoptosis in rat SCI models. SCI induced neutrophils infiltration when examined by myeloperoxidase activity, which was prevented by BMS-345541 through inhibiting the expression of ICAM-1. BMS-345541 inhibited activation of caspase-3, and attenuated apoptotic cell death in spinal cord by modulating Bcl-2 and Bax expression following SCI. Our study indicates that BMS-345541 may play an important role on the anti-inflammatory and anti-apoptotic effects with experimental SCI. Our results imply the IKK inhibitors may be useful in the therapy of spinal cord injury. |
| | |
Authors:
|
Xin Han; Ming Lu; Shouyu Wang; Decheng Lv; Hairun Liu |
Related Documents
:
|
22364128 - Role of translocator protein in renal ischemia reperfusion, renal preservation and acut... 12631618 - Significant antitumoral activity of cationic multilamellar liposomes containing human i... 6462628 - Enucleation-induced metastasis of intraocular melanomas in mice. 14768048 - Subversion of effector cd8+ t cell differentiation in acute hepatitis c virus infection... 22222708 - Muscarinic receptor agonists and antagonists: effects on inflammation and immunity. 10698968 - Best5: a novel interferon-inducible gene expressed during bone formation. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
|
Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
|
Department of Orthopedic Surgery, First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of elderly patients with glioblastoma: From clinical evidence to molecular highlights.
Next Document: Role of peripheral and spinal 5-HT(3) receptors in development and maintenance of formalin-induced l...