Document Detail

Targeting ALDH1A1 to treat pigmentary disorders.
MedLine Citation:
PMID:  23614737     Owner:  NLM     Status:  MEDLINE    
Clinical disorders related to skin pigmentation include hypo- or hyperpigmentation. Because they are difficult to treat, new approaches to develop safe pigment modulatory agents are needed. In the March issue of the journal, Paterson et al. (Exp Dermatol, 22, 2013) determined which aldehyde dehydrogenase 1A1 (ALDH1A1) substrates and products regulate melanogenesis. The authors demonstrated that ALDH1A1 substrate 9-cis retinal and its corresponding product 9-cis retinoic acid potently induced the accumulation of MITF mRNA, tyrosinase mRNA and melanin. Despite depletion of ALDH1A1, there was observed decreased ability of 9-cis retinal but not 9-cis retinoic acid to stimulate melanogenesis, indicating that ALDH1A1 regulates melanogenesis by catalysing the conversion of 9-cis retinal to 9-cis retinoic acid. Additionally, potent ALDH1A1 inhibitor such as cyanamide or Angeli's salt significantly suppressed pigmentation in human skin cells. These findings provide new candidate agents for the treatment of hypo- or hyperpigmentation disorders, using novel pigmentation-modulatory agents that target ALDH1A1.
Konrad Kleszczynski; Andrzej T Slominski
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Experimental dermatology     Volume:  22     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-11-07     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  316-7     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
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MeSH Terms
Aldehyde Dehydrogenase / metabolism*
Melanins / metabolism*
Skin / metabolism*
Skin Pigmentation / physiology*
Tretinoin / metabolism*
Grant Support
Reg. No./Substance:
0/Melanins; 5688UTC01R/Tretinoin; EC Dehydrogenase
Comment On:
Exp Dermatol. 2013 Mar;22(3):202-9   [PMID:  23489423 ]

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