| Targeting of AID-mediated sequence diversification to immunoglobulin genes. | |
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MedLine Citation:
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PMID: 21295456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activation-induced cytidine deaminase (AID) is a key enzyme for antibody-mediated immune responses. Antibodies are encoded by the immunoglobulin genes and AID acts as a transcription-dependent DNA mutator on these genes to improve antibody affinity and effector functions. An emerging theme in field is that many transcribed genes are potential targets of AID, presenting an obvious danger to genomic integrity. Thus there are mechanisms in place to ensure that mutagenic outcomes of AID activity are specifically restricted to the immunoglobulin loci. Cis-regulatory targeting elements mediate this effect and their mode of action is probably a combination of immunoglobulin gene specific activation of AID and a perversion of faithful DNA repair towards error-prone outcomes. |
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Authors:
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Naga Rama Kothapalli; Sebastian D Fugmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2011-02-02 |
Journal Detail:
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Title: Current opinion in immunology Volume: 23 ISSN: 1879-0372 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-06-01 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 184-9 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Molecular Immunology Unit, Laboratory of Molecular Biology and Immunology, National Institute on Aging/National Institutes of Health, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytidine Deaminase / genetics, immunology* Genes, Immunoglobulin* Genome Humans Mutation Regulatory Sequences, Nucleic Acid |
| Grant Support | |
ID/Acronym/Agency:
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ZIA AG000387-06/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.5.4.-/AICDA (activation-induced cytidine deaminase); EC 3.5.4.5/Cytidine Deaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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