Document Detail


Targeted drug delivery to macrophages.
MedLine Citation:
PMID:  23289618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Targeted drug delivery to the macrophages appears to be an attractive proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.
AREAS COVERED: This review discusses the current status and utilization of various micro- as well as nanocarriers like microspheres/microparticles, liposomes, nanoparticles, dendrimers, niosomes, and carbon nanotubes for targeted delivery of bioactives to the macrophages.
EXPERT OPINION: The design of nanocarriers for cell-mediated drug delivery may differ from those used for conventional drug delivery systems. The literature review shows that nanocarriers could supplement sustained drug delivery to the macrophages, extended duration of action, reduced therapeutic dose, improved patient compliance, and reduced adverse effects of highly toxic, potent drugs. There is still a need to identify more specific receptors that are responsible for macrophage targeting. The identification of such receptors may also facilitate drug targeting to further specific parts of the body containing different types of macrophages.
Authors:
Narendra K Jain; Vijay Mishra; Neelesh Kumar Mehra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-06
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-05-20     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  353-67     Citation Subset:  IM    
Affiliation:
Dr. H. S. Gour Central University, Department of Pharmaceutical Sciences, Pharmaceutics Research Laboratory, Sagar M.P. - 470003, India. jnarendr@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Carriers / chemistry
Drug Delivery Systems / methods*
Humans
Macrophages / drug effects*
Pharmaceutical Preparations / administration & dosage*
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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