Document Detail

Targeted disruption of the mouse Lipoma Preferred Partner gene.
MedLine Citation:
PMID:  19111675     Owner:  NLM     Status:  MEDLINE    
LPP (Lipoma Preferred Partner) is a zyxin-related cell adhesion protein that is involved in the regulation of cell migration. We generated mice with a targeted disruption of the Lpp gene and analysed the importance of Lpp for embryonic development and adult functions. Aberrant Mendelian inheritance in heterozygous crosses suggested partial embryonic lethality of Lpp(-/-) females. Fertility of Lpp(-/-) males was proven to be normal, however, females from Lpp(-/-) x Lpp(-/-) crosses produced a strongly reduced number of offspring, probably due to a combination of female embryonic lethality and aberrant pregnancies. Apart from these developmental and reproductive abnormalities, Lpp(-/-) mice that were born reached adulthood without displaying any additional macroscopic defects. On the other hand, Lpp(-/-) mouse embryonic fibroblasts exhibited reduced migration capacity, reduced viability, and reduced expression of some Lpp interaction partners. Finally, we discovered a short nuclear form of Lpp, expressed mainly in testis via an alternative promoter.
Hilke B V K Vervenne; Koen R M O Crombez; Els L Delvaux; Veerle Janssens; Wim J M Van de Ven; Marleen M R Petit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-26
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  379     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  IM    
Laboratory for Molecular Oncology, Department of Human Genetics, Herestraat 49, Box 602, K.U. Leuven, Leuven, Belgium.
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MeSH Terms
Cell Nucleus / metabolism
Cytoskeletal Proteins / genetics,  metabolism,  physiology*
Embryo Loss / genetics
Embryonic Development / genetics*
Fertility / genetics*
Fibroblasts / metabolism
Gene Targeting
Mice, Knockout
Promoter Regions, Genetic
Protein Biosynthesis / genetics
Reproduction / genetics
Testis / metabolism
Transcription, Genetic
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Lpp protein, mouse

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