| Targeted delivery of nucleic-acid-based therapeutics to the pulmonary circulation. | |
| | |
MedLine Citation:
|
PMID: 19132538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary endothelium may become a novel therapy for the treatment of various types of lung diseases. It may also provide a new research tool to study the functions and regulation of novel genes in pulmonary endothelium. Its success is largely dependent on the development of a vehicle that is capable of efficient pulmonary delivery with minimal toxicity. This review summarizes the recent progress that has been made in our laboratory along these research directions. Factors that affect pulmonary nucleic acids delivery are also discussed. |
| | |
Authors:
|
Ramalinga Kuruba; Annette Wilson; Xiang Gao; Song Li |
Related Documents
:
|
8837028 - Enzymatic labeling of nucleic acids. 18058498 - Synthesis of fluorinated indoles as rna analogues. 19153138 - A self-cleaving dna enzyme modified with amines, guanidines and imidazoles operates ind... 18968108 - Ftir spectroscopy studies of nucleic acid damage. 6872948 - N-alpha-formyl-tyrosyl-relaxin - a reliable tracer for relaxin radioimmunoassay. 3148458 - Changes in urinary amino acid fractional excretion in neonates undergoing total parente... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-01-09 |
Journal Detail:
|
Title: The AAPS journal Volume: 11 ISSN: 1550-7416 ISO Abbreviation: AAPS J Publication Date: 2009 Mar |
Date Detail:
|
Created Date: 2009-04-03 Completed Date: 2009-07-23 Revised Date: 2010-09-22 |
Medline Journal Info:
|
Nlm Unique ID: 101223209 Medline TA: AAPS J Country: United States |
Other Details:
|
Languages: eng Pagination: 23-30 Citation Subset: IM |
Affiliation:
|
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Animals Antigens, Surface / drug effects Cations / pharmacokinetics Dependovirus / genetics Drug Carriers / administration & dosage, pharmacokinetics Drug Delivery Systems / methods* Endothelial Cells / drug effects Gene Therapy / methods Genetic Vectors / administration & dosage, pharmacokinetics Humans Injections, Intravenous Lipids / administration & dosage, pharmacokinetics Liposomes / administration & dosage, pharmacokinetics Lung / blood supply*, cytology Mice Nucleic Acids / administration & dosage, pharmacokinetics*, therapeutic use Oligonucleotides / administration & dosage, pharmacokinetics, therapeutic use Peptides / administration & dosage, pharmacokinetics Polymers / pharmacokinetics Pulmonary Circulation* RNA, Small Interfering / administration & dosage, pharmacokinetics, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
|
HL-63080/HL/NHLBI NIH HHS; HL-68688/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Surface; 0/Cations; 0/Drug Carriers; 0/Lipids; 0/Liposomes; 0/Nucleic Acids; 0/Oligonucleotides; 0/Peptides; 0/Polymers; 0/RNA, Small Interfering |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polymeric matrix system for prolonged delivery of tramadol hydrochloride, part I: physicochemical ev...
Next Document: Maximizing resources to study an uncommon cancer: E2C2--Epidemiology of Endometrial Cancer Consortiu...