| Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer. | |
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MedLine Citation:
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PMID: 19943768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Application of daunorubicin in treatment of leukemia has been limited for its side effects like cardiotoxicity. Specific delivery of chemotherapy drugs is an important factor in decreasing their side effects. In this study, sgc8, an aptamer for protein tyrosine kinase-7 (PTK7), was used for specific delivery of daunorubicin to Molt-4 cells (PTK7(+)). Flow cytometric experiments showed that aptamer-daunorubicin complex was internalized effectively to Molt-4 cells (PTK7(+)), but not to U266 cells (PTK7(-)). This fact was confirmed by less cytotoxicity of aptamer-drug complex in U266 cells in compare to daunorubicin alone. No significant change in viability between daunorubicin and aptamer-daunorubicin complex treated Molt4 cells was observed. In conclusion, sgc8-daunorubicin complex is introduced as a simple and efficient system for targeted delivery of drug to acute lymphoblastic leukemia T cells. |
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Authors:
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Seyed Mohammad Taghdisi; Khalil Abnous; Fatemeh Mosaffa; Javad Behravan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of drug targeting Volume: 18 ISSN: 1029-2330 ISO Abbreviation: J Drug Target Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312476 Medline TA: J Drug Target Country: England |
Other Details:
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Languages: eng Pagination: 277-81 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage* Aptamers, Nucleotide / chemistry* Base Sequence Cell Line, Tumor Daunorubicin / administration & dosage* Drug Delivery Systems* Flow Cytometry Humans Nucleic Acid Conformation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology* Spectrometry, Fluorescence |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Aptamers, Nucleotide; 20830-81-3/Daunorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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