Document Detail


Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer.
MedLine Citation:
PMID:  19943768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Application of daunorubicin in treatment of leukemia has been limited for its side effects like cardiotoxicity. Specific delivery of chemotherapy drugs is an important factor in decreasing their side effects. In this study, sgc8, an aptamer for protein tyrosine kinase-7 (PTK7), was used for specific delivery of daunorubicin to Molt-4 cells (PTK7(+)). Flow cytometric experiments showed that aptamer-daunorubicin complex was internalized effectively to Molt-4 cells (PTK7(+)), but not to U266 cells (PTK7(-)). This fact was confirmed by less cytotoxicity of aptamer-drug complex in U266 cells in compare to daunorubicin alone. No significant change in viability between daunorubicin and aptamer-daunorubicin complex treated Molt4 cells was observed. In conclusion, sgc8-daunorubicin complex is introduced as a simple and efficient system for targeted delivery of drug to acute lymphoblastic leukemia T cells.
Authors:
Seyed Mohammad Taghdisi; Khalil Abnous; Fatemeh Mosaffa; Javad Behravan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of drug targeting     Volume:  18     ISSN:  1029-2330     ISO Abbreviation:  J Drug Target     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312476     Medline TA:  J Drug Target     Country:  England    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / administration & dosage*
Aptamers, Nucleotide / chemistry*
Base Sequence
Cell Line, Tumor
Daunorubicin / administration & dosage*
Drug Delivery Systems*
Flow Cytometry
Humans
Nucleic Acid Conformation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
Spectrometry, Fluorescence
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Aptamers, Nucleotide; 20830-81-3/Daunorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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