| Targeted deletion of Wwox reveals a tumor suppressor function. | |
| | |
MedLine Citation:
|
PMID: 17360458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The WW domain-containing oxidoreductase (WWOX) spans the second most common fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in several types of human cancer. We have previously shown that restoration of WWOX expression in cancer cells suppresses tumorigenicity. To investigate WWOX tumor suppressor function in vivo, we generated mice carrying a targeted deletion of the Wwox gene and monitored incidence of tumor formation. Osteosarcomas in juvenile Wwox(-/-) and lung papillary carcinoma in adult Wwox(+/-) mice occurred spontaneously. In addition, Wwox(+/-) mice develop significantly more ethyl nitrosourea-induced lung tumors and lymphomas in comparison to wild-type littermate mice. Intriguingly, these tumors still express Wwox protein, suggesting haploinsuffiency of WWOX itself is cancer predisposing. These results indicate that WWOX is a bona fide tumor suppressor. |
| | |
Authors:
|
Rami I Aqeilan; Francesco Trapasso; Sadiq Hussain; Stefan Costinean; Dean Marshall; Yuri Pekarsky; John P Hagan; Nicola Zanesi; Mohamed Kaou; Gary S Stein; Jane B Lian; Carlo M Croce |
Related Documents
:
|
19996208 - Integrated molecular and clinical analysis of akt activation in metastatic melanoma. 16027168 - Genetic analysis of pten and tsc2 functional interactions in the mouse reveals asymmetr... 7621068 - Oncogenes and tumor suppressor genes. 21986388 - New criteria for analyzing the statistical relationships between biological parameters ... 17663798 - Egfr associated expression profiles vary with breast tumor subtype. 16273208 - Vitamins k1 and k2 potentiate hyperthermia by down-regulating hsp72 expression in vitro... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-02-27 |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 104 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-03-15 Completed Date: 2007-04-24 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
|
Languages: eng Pagination: 3949-54 Citation Subset: IM |
Affiliation:
|
Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, USA. rami.aqeilan@osumc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinoma / genetics, metabolism Gene Deletion* Gene Expression Regulation, Neoplastic* Genes, Tumor Suppressor* Genome Humans Lung Neoplasms / genetics, metabolism Lymphoma / genetics, metabolism Mice Mice, Knockout Mice, Transgenic Osteosarcoma / metabolism Oxidoreductases / genetics* Phenotype |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AR 048818/AR/NIAMS NIH HHS; P01 CA 082834/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
EC 1.-/Oxidoreductases; EC 1.-/Wwox protein, mouse |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of a...
Next Document: Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA b...